In this article, you can read the instructions for use of the drug. Metoclopramide. Presented reviews of visitors to the site – the consumers of this medication, as well as the opinions of specialists in the use of Metoclopramide in their practice A big request to add your feedback on the drug more actively: the medicine helped or did not help to get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogs of Metoclopramide in the presence of available structural analogues. Use for the treatment of nausea, vomiting and flatulence in adults, children, as well as during pregnancy and breastfeeding.
Metoclopramide – antiemetic. A specific blocker of dopamine (D2) and serotonin (5-NTZ) receptors, inhibits chemoreceptors of the trigger region of the brain stem, weakens the sensitivity of the visceral nerves, transmitting impulses from the pylorus of the stomach and duodenum to the emetic center. Through the hypothalamus and the parasympathetic nervous system (innervation of the gastrointestinal tract) has a regulating and coordinating effect on the tone and motor activity of the upper GI tract (in
The onset of action on the gastrointestinal tract occurs within 1-3 minutes after intravenous administration, 10-15 minutes after intramuscular administration and is manifested by the acceleration of the evacuation of the stomach contents (approximately from
Metoclopramide hydrochloride + excipients.
Communication with plasma proteins is about 30%. Metabolized in the liver. The half-life is 4-6 hours, in case of impaired renal function – up to 14 hours.
The removal of the drug occurs mainly through the kidneys within 24-72 hours in unchanged form and in the form of conjugates. Passes through the placental and blood-brain barriers and penetrates into the mother’s milk.
- vomiting, nausea, hiccups of various origins (in some cases, it can be effective with vomiting caused by radiation therapy or cytotoxic drugs);
- atony and hypotonia of the stomach and intestines (in particular, postoperative);
- hypomotor dyskinesia of the biliary tract;
- reflux esophagitis;
- functional pyloric stenosis;
- as part of the treatment of acute gastric and duodenal ulcers;
- used to enhance peristalsis when conducting radiopaque studies of the gastrointestinal tract;
- as a means of facilitating duodenal intubation (to accelerate gastric emptying and the movement of food through the small intestine).
Forms of release
Solution for intravenous and intramuscular administration (pricks in ampoules for injections).
Instructions for use and dosage
Tablets are taken 30 minutes before a meal, washed down with a small amount of water. Adults – 5-10 mg 3-4 times a day. The maximum single dose – 20 mg daily – 60 mg. Children over 6 years old – 5 mg 1-3 times a day.
Intravenous or intramuscular.
Adults in a dose of 10-20 mg 1-3 times a day (maximum daily dose – 60 mg). Children older than 6 years, 5 mg 1-3 times a day.
For the prevention and treatment of nausea and vomiting caused by the use of cytostatics or radiation therapy, the drug is administered intravenously at a dose of 2 mg / kg body weight 30 minutes before the use of cytostatics or radiation; If necessary, repeat the introduction after 2-3 hours.
Before X-ray examination, adults injected 10-20 mg intravenously for 5-15 minutes before the start of the study.
Patients with clinically severe hepatic and / or renal insufficiency are prescribed a dose twice the usual dose, the subsequent dose depends on the patient’s individual response to metoclopramide.
- spasm of the facial muscles;
- rhythmic protrusion of the tongue;
- bulbar type of speech;
- spasm of extraocular muscles (including ocular incidence);
- spastic torticollis;
- muscle hypertonus;
- Parkinsonism (hyperkinesis, muscular rigidity – manifestation of dopamine-blocking action, the risk of development in children and adolescents increases when the dose of 0.5 mg / kg per day is exceeded);
- dyskinesias (in the elderly, in chronic renal failure);
- noise in ears;
- constipation or diarrhea;
- dry mouth;
- neutropenia, leukopenia, sulfhemoglobinemia in adults;
- atrioventricular block;
- violation of the menstrual cycle;
- hyperemia of the nasal mucosa.
- bleeding from the gastrointestinal tract;
- pyloric stenosis;
- mechanical intestinal obstruction;
- perforation of the wall of the stomach or intestines;
- extrapyramidal disorders;
- Parkinson’s disease;
- prolactin-dependent tumors;
- vomiting during treatment or overdose with neuroleptics and in patients with breast cancer;
- bronchial asthma in patients with hypersensitivity to sulfites;
- pregnancy (1 trimester), lactation;
- Early childhood (metoclopramide is contraindicated in the form of any dosage forms for children under 2 years of age; parenteral administration is contraindicated for children under 6 years of age);
- hypersensitivity to metoclopramide or any of the components of the drug;
- after gastrointestinal surgery (such as pyloroplasty or intestinal anastomosis), as vigorous muscle contractions prevent healing.
Use during pregnancy and lactation
Metoclopramide is contraindicated for use in the first trimester of pregnancy. Use in 2 and 3 trimesters of pregnancy is possible only for health reasons.
If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.
Use in children
It is contraindicated in early childhood (use of metoclopramide in the form of any dosage forms is contraindicated in children under 2 years of age, parenteral administration is contraindicated in children under 6 years of age).
The use of the drug in children causes an increased risk of dyskinetic syndrome.
Not effective with vomiting of vestibular genesis.
In connection with the content of sodium sulfite, injectable solution of metoclopramide should not be administered to patients with bronchial asthma, who are hypersensitive to sulfites. Against the background of the use of metoclopramide, data may be distorted by laboratory parameters of liver function and determine the concentration of aldosterone and prolactin in plasma.
Most side effects occur within 36 hours from the start of treatment and disappear within 24 hours after withdrawal. Treatment should be, if possible, short-term.
During the period of drug treatment is not recommended alcohol.
Influence on ability to drive motor transport and control mechanisms
It is recommended to be careful when driving a vehicle or when working with potentially dangerous mechanisms that require high concentration of attention and speed of psychomotor reactions.
Enhances the effect of ethanol (alcohol) on the central nervous system, the sedative effect of hypnotic drugs, increases the effectiveness of therapy with H2-histamine receptor blockers.
Increases absorption of diazepam, tetracycline, ampicillin, paracetamol, acetylsalicylic acid, levodopa, ethanol (alcohol); slows down the absorption of digoxin and cimetidine.
With simultaneous use with neuroleptics increases the risk of extrapyramidal symptoms.
The action of metoclopramide can weaken cholinesterase inhibitors.
If you are taking other drugs, you should consult with your doctor.
Analogs of the drug Metoclopramide
Structural analogues of the active substance:
- Apo Metoclop;
- Metoclopramide Acre;
- Metoclopramide Vial;
- Metoclopramide Darnitsa;
- Metoclopramide Promed;
- Metoclopramide Eskom;
- Metoclopramide hydrochloride;
Analogs for the therapeutic effect (antiemetics):
- Aviation Planner;
- Apo Metoclop;
- Vero Ondansetron;
- Trifluoperazin Apo;
- Эта eperapine.