In this article, you can read the instructions for use of the drug. Mildronat. Presented reviews of visitors to the site – the consumers of this medicine, as well as the opinions of medical experts on the use of Mildronata in their practice. A big request to add your feedback on the drug more actively: the medicine helped or did not help to get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogs Mildronata in the presence of available structural analogues. Use for the treatment of heart attacks and strokes and improve tissue metabolism in adults, children, as well as during pregnancy and breastfeeding.
Mildronat – drug that improves metabolism. Meldonium (active ingredient of the drug Mildronate) is a structural analogue of gamma-butyrobetaine, a substance that is found in every cell of the human body.
Under the conditions of increased load, Mildronate restores the balance between the delivery and the need of cells for oxygen, eliminates the accumulation of toxic metabolic products in the cells, protecting them from damage; also has a tonic effect. As a result of its use, the body acquires the ability to withstand the load and quickly restore energy reserves. Due to these properties, Mildronate is used to treat various disorders of the cardiovascular system, the blood supply to the brain, as well as enhance physical and mental performance.
As a result of a decrease in the concentration of carnitine, gamma-butyrobetaine, which has vasodilating properties, is intensively synthesized. In acute ischemic myocardial damage, Mildronate slows down the formation of a necrotic zone, shortens the rehabilitation period.
In heart failure, the drug increases myocardial contractility, increases exercise tolerance, and reduces the frequency of strokes.
In acute and chronic ischemic disorders of cerebral circulation improves blood circulation in the ischemic focus, promotes the redistribution of blood in favor of the ischemic area.
Effective with vascular and dystrophic pathology of the fundus.
The drug eliminates functional disorders of the nervous system, developing on the background of a long-term alcohol intake in patients with chronic alcoholism with withdrawal syndrome.
After ingestion, the drug is rapidly absorbed from the gastrointestinal tract. Metabolized in the body to form two major metabolites that are excreted by the kidneys.
- as part of complex therapy of coronary artery disease (angina, myocardial infarction), chronic heart failure, dyshormonal cardiomyopathy;
- in the complex treatment of acute and chronic disorders of cerebral circulation (strokes and cerebrovascular insufficiency);
- reduced performance;
- physical overvoltage (in
Forms of release
250 mg and 500 mg capsules (sometimes mistakenly called tablets, but the tablet form of Mildronate does not exist)
Solution for intravenous, intramuscular and parabulbar injections (pricks in ampoules).
Instructions for use and dosing regimen
In connection with the possibility of the development of a stimulating effect, the drug is recommended to be used in the first half of the day.
In case of cardiovascular diseases as part of complex therapy, the drug is prescribed orally in a dose of
In case of cardialgia on the background of dyshormonal dystrophy of myocardium, Mildronate is administered orally 250 mg twice a day. The course of treatment is 12 days.
In case of violation of cerebral circulation in the acute phase, the drug is administered intravenously (in the appropriate dosage form, 500 mg 1 time per day for 10 days), then transferred to taking the drug inside by
In chronic cerebral circulatory disorders, the drug is taken orally by
When mental and physical exertion is prescribed inside of 250 mg 4 times a day. The course of treatment is 10-14 days. If necessary, therapy is repeated after 2-3 weeks.
Athletes are recommended to apply for
In chronic alcoholism, the drug is prescribed inside of 500 mg 4 times a day. The course of treatment is 7-10 days.
In case of cardiovascular diseases as part of complex therapy, the drug is prescribed in a dose of
In case of violation of cerebral circulation in the acute phase, the drug is prescribed in / in 500 mg once a day for 10 days, then transferred to the drug intake (in the appropriate dosage form – by
In vascular pathology and dystrophic diseases of the retina, Mildronate is administered parabulbally along
For mental and physical exertion, 500 mg is prescribed intravenously in a dose of 500 mg once a day. The course of treatment is 10-14 days. If necessary, therapy is repeated after 2-3 weeks.
In chronic alcoholism, the drug is prescribed in / in the 500 mg 2 times a day. The course of treatment is 7-10 days.
- changes in blood pressure;
- psychomotor agitation;
- dyspeptic symptoms;
- allergic reactions (reddening of the skin, rash or rash, itchy skin, swelling);
- general weakness;
- increased intracranial pressure (in
Use during pregnancy and lactation
The safety of Mildronate during pregnancy has not been proven. In order to avoid possible adverse effects on the fetus, the drug should not be prescribed during pregnancy.
It is not known whether the drug is excreted in breast milk. If necessary, use Mildronata during lactation breastfeeding should be discontinued.
Patients with chronic liver and kidney disease should be careful with long-term use of the drug. If necessary, a long (more than a month) use of the drug should be consulted with a specialist.
Long-term experience in the treatment of acute myocardial infarction and unstable angina in the cardiology departments shows that Mildronate is not a first-line drug for acute coronary syndrome.
Use in Pediatrics
In children and adolescents under the age of 18, the efficacy and safety of Mildronate in the form of capsules and injection solution has not been established.
Influence on ability to drive motor transport and control mechanisms
Data on the adverse effects of Mildronate on the speed of the psychomotor reaction is not available.
When used together, Mildronate enhances the action of antianginal drugs, certain antihypertensive drugs, and cardiac glycosides.
Mildronate can be combined with antianginal drugs, anticoagulants and antiplatelet agents, antiarrhythmic drugs, diuretics, bronchodilators.
When combined with nitroglycerin, nifedipine, alpha-blockers, antihypertensive drugs and peripheral vasodilators with Mildronate, mild tachycardia and arterial hypotension may develop (use caution when using this combination).
Analogs of the drug Mildronat
Structural analogues of the active substance:
- 3- (2,2,2-Trimethylhydrazinium) propionate dihydrate;
- Meldonia dihydrate;
- Trimethylhydrazinium propionate dihydrate.